Why Sequencing DNA In Space Is A Big Deal

Why Sequencing DNA in Space is a Big Deal

... And How You Can Talk to the Scientists Who Made It Happen

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Less than one month ago, DNA had never been sequenced in space. As of today, more than one billion base pairs of DNA have been sequenced aboard the International Space Station, Earth’s only orbiting laboratory. The ability to sequence the DNA of living organisms in space opens a whole new world of scientific and medical possibilities. Scientists consider it a game changer. 

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NASA astronaut Kate Rubins, who has a background in genomics, conducted the sequencing on the space station as part of the Biomolecule Sequencer investigation. A small, commercial, off-the-shelf device called MinION (min-EYE-ON), manufactured by Oxford Nanopore Technologies in the UK, was used to sequence the DNA of bacteria, a virus and rodents. Human DNA was not sequenced, and there are no immediate plans to sequence human DNA in space. 

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(Image Credit: Oxford Nanopore Technologies)

The MinION is about the size of a candy bar, and plugs into a laptop or tablet via USB connection, which also provides power to the device. The tiny, plug and play sequencer is diminutive compared to the large microwave-sized sequencers used on Earth, and uses much less power. Unlike other terrestrial instruments whose sequencing run times can take days, this device’s data is available in near real time; analysis can begin within 10-15 minutes from the application of the sample.

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Having real-time analysis capabilities aboard the space station could allow crews to identify microbes, diagnose infectious disease and collect genomic and genetic data concerning crew health, without having to wait long periods of time to return samples to Earth and await ground-based analysis.

The first DNA sequencing was conducted on Aug. 26, and on Sept. 14, Rubins and the team of scientists back at NASA’s Johnson Space Center in Houston hit the one-billionth-base-pairs-of-DNA-sequenced mark.

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Have more questions about how the Biomolecule Sequencer works, or how it could benefit Earth or further space exploration? Ask the team of scientists behind the investigation, who will be  available for questions during a Reddit Ask Me Anything on /r/science on Wednesday, Sept. 28 at 2 p.m. EDT. 

The participants are:

Dr. Aaron Burton, NASA Johnson Space Center, Planetary Scientist and Principal Investigator

Dr. Sarah Castro-Wallace, NASA Johnson Space Center, Microbiologist and Project Manager

Dr. David J. Smith, NASA Ames Research Center, Microbiologist

Dr. Mark Lupisella, NASA Goddard Space Flight Center, Systems Engineer

Dr. Jason P. Dworkin, NASA Goddard Space Flight Center, Astrobiologist

Dr. Christopher E. Mason, Weill Cornell Medicine Dept. of Physiology and Biophysics, Associate Professor

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3 years ago

What sparked your interest in science?


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5 years ago

The Rover Doctor is in: The Anatomy of a NASA Human Exploration Rover Challenge Rover

Exploration and inspiration collide head-on in our Human Exploration Rover Challenge held near Marshall Space Flight Center in Huntsville, Alabama, each April. The annual competition challenges student teams from around the world to design, build and drive a human-powered rover over a punishing half-mile course with tasks and obstacles similar to what our astronauts will likely have on missions to the Moon, Mars and beyond.

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The anatomy of the rover is crucial to success. Take a look at a few of the vital systems your rover will need to survive the challenge!

The Chassis

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A rover’s chassis is its skeleton and serves as the framework that all of the other rover systems attach to. The design of that skeleton incorporates many factors: How will your steering and braking work? Will your drivers sit beside each other, front-to-back or will they be offset? How high should they sit? How many wheels will your rover have? All of those decisions dictate the design of your rover’s chassis.

Wheels

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Speaking of wheels, what will yours look like? The Rover Challenge course features slick surfaces, soft dunes, rocky craters and steep hills – meaning your custom-designed wheels must be capable of handling diverse landscapes, just as they would on the Moon and Mars. Carefully cut wood and cardboard, hammer-formed metal and even 3-D printed polymers have all traversed the course in past competitions.

Drivetrain

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You’ve got your chassis design. Your wheels are good to go. Now you have to have a system to transfer the energy from your drivers to the wheels – the drivetrain. A good drivetrain will help ensure your rover crosses the finish line under the 8-minute time limit. Teams are encouraged to innovate and think outside the traditional bike chain-based systems that are often used and often fail. Exploration of the Moon and Mars will require new, robust designs to explore their surfaces. New ratchet systems and geared drivetrains explored the Rover Challenge course in 2019.

Colors and Gear

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Every good rover needs a cool look. Whether you paint it your school colors, fly your country’s flag or decorate it to support those fighting cancer (Lima High School, above, was inspired by those fighting cancer), your rover and your uniform help tell your story to all those watching and cheering you on. Have fun with it!

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Are you ready to conquer the Rover Challenge course? Join us in Huntsville this spring! Rover Challenge registration is open until January 16, 2020 for teams based in the United States.

If building rovers isn’t your space jam, we have other Artemis Challenges that allow you to be a part of the NASA team – check them out here.

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Want to learn about our Artemis program that will land the first woman and next man on the Moon by 2024? Go here to read about how NASA, academia and industry and international partners will use innovative technologies to explore more of the lunar surface than ever before. Through collaborations with our commercial, international and academic partners, we will establish sustainable lunar exploration by 2028, using what we learn to take astronauts to Mars. 

The students competing in our Human Exploration Rover Challenge are paramount to that exploration and will play a vital role in helping NASA and all of humanity explore space like we’ve never done before!

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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7 years ago
Our Cassini Spacecraft Has Been Traveling In Space For Almost 20 Years, Exploring Saturn, Its Rings And

Our Cassini spacecraft has been traveling in space for almost 20 years, exploring Saturn, its rings and even some of its moons. This mission has revealed never-before-seen events that are changing our understanding of how planetary systems form and what conditions might lead to habitats for life.

Cassini will complete its remarkable story of exploration with an intentional plunge into Saturn’s atmosphere, ending its mission.  

Participate in our Grand Finale Events

Wednesday, Sept. 13

1 p.m. EDT – News Conference from our Jet Propulsion Laboratory with a detailed preview of final mission activities Watch HERE.

Thursday, Sept 14

4:00 - 5:00 p.m. EDT - NASA Social Live Broadcast with mission experts Watch HERE.

Friday, Sept. 15

7:00 – 8:30 a.m. EDT – Live commentary on NASA TV and online of the spacecraft’s final dive into Saturn’s atmosphere. Watch HERE.

Around 8:00 a.m. EDT – Expected time of last signal and science data from Cassini Watch HERE.

9:30 a.m. EDT – Post-mission news conference Watch HERE.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.


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5 years ago

What does a normal day for you consist of?


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9 years ago

Fun Facts About Mars

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Mars is a cold desert world, and is the fourth planet from the sun. It is half the diameter of Earth and has the same amount of dry land. Like Earth, Mars has seasons, polar ice caps, volcanoes, canyons and weather, but its atmosphere is too thin for liquid water to exist for long on the surface. There are signs of ancient floods on the Red Planet, but evidence for water now exists mainly in icy soil and thin clouds.

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Earth has one, Mars has two…moons of course! Phobos (fear) and Deimos (panic) are the Red Planet’s two small moons. They are named after the horses that pulled the chariot of the Greek war god Ares, the counterpart to the Roman war god Mars.

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The diameter of Mars is 4220 miles (6792 km). That means that the Red Planet is twice as big as the moon, but the Earth is twice as big as Mars.

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Since Mars has less gravity than Earth, you would weigh 62% less than you do here on our home planet. Weigh yourself here on the Planets App. What’s the heaviest thing you’ve ever lifted? On Mars, you could have lifted more than twice that! Every 10 pounds on Earth only equals 4 pounds on the Red Planet. Find out why HERE.

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Mass is the measurement of the amount of matter something contains. Mars is about 1/10th of the mass of Earth.

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Mars and Earth are at their closest point to each other about every two years, with a distance of about 33 million miles between them at that time. The farthest that the Earth and Mars can be apart is: 249 million miles. This is due to the fact that both Mars and Earth have elliptical orbits and Mars’ orbit is tilted in comparison with the Earth’s. They also orbit the sun at different rates.

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The temperature on Mars can be as high as 70 degrees Fahrenheit (20 degrees Celsius) or as low as about –225 degrees Fahrenheit (-153 degrees Celsius). How hot or cold the surface varies between day and night and among seasons. Mars is colder than Earth because it is farther from the sun.

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You know that onions have layers, but did you know that Mars has layers too? Like Earth, Mars has a crust, a mantle and a core. The same stuff even makes up the planet layers: iron and silicate.

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Ever wonder why it’s so hard launching things to space? It’s because the Earth has a log of gravity! Gravity makes things have weight, and the greater the gravity, the more it weights. On Mars, things weigh less because the gravity isn’t as strong.

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Take a deep breath. What do you think you just breathed in? Mostly Nitrogen, about a fifth of that breath was Oxygen and the rest was a mix of other gases. To get the same amount of oxygen from one Earth breath, you’d have to take around 14,500 breaths on Mars! With the atmosphere being 100 times less dense, and being mostly carbon dioxide, there’s not a whole lot of oxygen to breathe in.

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Mars has about 15% of Earth’s volume. To fill Earth’s volume, it would take over 6 Mars’ volumes.

For more fun Mars facts, visit HERE.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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9 years ago

5 Myths About Becoming an Astronaut

Editor’s Note: This post was updated on March 15, 2024, to reflect new URLs and updated qualifications for applicants.

Have you ever wondered if you have what it takes to become a NASA astronaut? The term “astronaut” derives from the Greek word meaning “star sailor.”

We’re looking for a new class of astronauts to join the NASA team, and if you’re thinking about applying, there are a few things you should know.

Here are a few myths about becoming an astronaut:

MYTH: All astronauts have piloting experience.

FACT: You don’t need to be a pilot to be an astronaut. Flying experience is not a requirement, but it could be beneficial to have.

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MYTH: All astronauts have perfect vision.

FACT: It’s OK if you don’t have 20/20 vision. As of September 2007, corrective surgical procedures of the eye (PRK and LASIK), are now allowed, providing at least one year has passed since the date of the procedure with no permanent adverse aftereffects.

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MYTH: All astronauts have advanced degrees, like a PhD.

FACT: While a master’s degree from an accredited university is typically necessary to become an astronaut, an exception exists if you have completed a medical degree or test pilot school.

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MYTH: Astronauts are required to have military experience to be selected.

FACT: Military experience is not required to become an astronaut.

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MYTH: You must be a certain age to be an astronaut. 

FACT: There are no age restrictions. Astronaut candidates selected in the past have ranged between the ages of 26 and 46, with the average age being 34.

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OK, but what are the requirements?

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Basic Qualification Requirements

Applicants must meet the following minimum requirements before submitting an application:

Be a U.S. citizen.

Have completed a master’s degree (or foreign equivalent) in an accredited college or university with major study in an appropriate technical field of engineering, biological science, physical science, computer science, or mathematics.

The master’s degree requirement can also be met by having:

Completed at least two years (36 semester hours or 54 quarter hours) in an accredited PhD or related doctoral degree program (or foreign equivalent) with major study in an appropriate technical field of engineering, biological science, physical science, computer science, or mathematics.

Completed a Doctor of Medicine, Doctor of Osteopathic Medicine, or related medical degree (or foreign equivalent) in an accredited college or university.

Completed or be currently enrolled in a Test Pilot School (TPS) program (nationally or internationally recognized) and will have completed this program by June 2025. (Must submit proof of completion or enrollment.)

If TPS is your only advanced technical degree, you must have also completed a bachelor’s degree or higher (or foreign equivalent) at an accredited college or university with major study in an appropriate technical field of engineering, biological science, physical science, computer science, or mathematics.

Have at least three years of related professional experience obtained after degree completion (or 1,000 Pilot-in-Command hours with at least 850 of those hours in high-performance jet aircraft for pilots). For medical doctors, time in residency can count toward experience and must be completed by June 2025.

Be able to pass the NASA long-duration flight astronaut physical.

Applications for our next astronaut class are open through April 16! Learn more about our Astronaut Selection Program and check out current NASA astronaut Anne McClain’s advice in “An Astronaut’s Guide to Applying to Be an Astronaut.”

Make sure to follow us on Tumblr for your regular dose of space!

Image Descriptions 1. GIF showing a first-person view from the cockpit of a T-38 NASA training jet. The camera pans 360 degrees to show the the sky, the jet’s wing, and the astronaut in training wearing a flight helmet. The sky is reflected n the astronaut’s visor. Credit: NASA

2. Two astronauts smiling inside a module aboard the International Space Station. They’re wearing casual clothes. At left, the man is wearing a navy blue crew neck shirt. At right, the woman is wearing a red crew neck shirt. Credit: NASA

3. Four astronauts floating inside a module aboard the International Space Station. The two outermost astronauts are wearing shirts that say M.I.T. on them. The two in the middle have hats that say M.I.T. on them. The second astronaut from the left holds up a red flag representing M.I.T. They’re all smiling. Credit: NASA

4. Two astronauts float inside a module aboard the International Space Station. They’re both wearing t-shirts that say NAVY on them. Credit: NASA

5. GIF showing six International Space Station crew members having a meal together. They’re eating and drinking from food pouches. Credit: NASA

6. A graphic displaying NASA's astronaut requirements, which are detailed in the text below the image. An astronaut in a spacesuit, pointing to the reader, is peeking out of the right side of the image, and the surface of the Moon takes up most of the image's background. "NASA's 2024 Astronaut Recruitment" is in large text in the image's bottom-left corner. Credit: NASA


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8 years ago
Wispy Remains Of A Supernova Explosion Hide A Possible 'survivor.' Of All The Varieties Of Exploding

Wispy remains of a supernova explosion hide a possible 'survivor.' Of all the varieties of exploding stars, the ones called Type Ia are perhaps the most intriguing. Their predictable brightness lets astronomers measure the expansion of the universe, which led to the discovery of dark energy. Yet the cause of these supernovae remains a mystery. Do they happen when two white dwarf stars collide? Or does a single white dwarf gorge on gases stolen from a companion star until bursting? If the second theory is true, the normal star should survive. Astronomers used the Hubble Space Telescope to search the gauzy remains of a Type Ia supernova in a neighboring galaxy called the Large Magellanic Cloud. They found a sun-like star that showed signs of being associated with the supernova. Further investigations will be needed to learn if this star is truly the culprit behind a white dwarf's fiery demise.

 This supernova remnant is located 160,000 light-years from Earth. The actual supernova remnant is the irregular shaped dust cloud, at the upper center of the image. The gas in the lower half of the image and the dense concentration of stars in the lower left are the outskirts of a star cluster.

Image credit: NASA, ESA and H.-Y. Chu (Academia Sinica, Taipei)


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6 years ago

Welcome Home HERA Mission XVII!

With the Human Exploration Research Analog (HERA) habitat, we complete studies to prepare us for exploration to asteroids, Mars, and the Moon… here on Earth! The studies are called analogs, and they simulate space missions to study how different aspects of deep space affect humans. During a HERA mission, the crew (i.e., the research participants) live and work very much as astronauts do, with minimal contact with anyone other than Mission Control for 45 days.

The most recent study, Mission XVII, just “returned to Earth” on June 18. (i.e., the participants egressed, or exited the habitat at our Johnson Space Center in Houston after their 45-day study.) We talked with the crew, Ellie, Will, Chi, and Michael, about the experience. Here are some highlights!

Why did you decide to participate in HERA Mission XVII?

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HERA Mission VXII participants (from left to right) Ellie, Will, Chi, and Michael.

“My master’s is in human factors,” said Chi, who studies the interaction between humans and other systems at Embry-Riddle Aeronautical University. “I figured this would be a cool way to study the other side of the table and actually participate in an analog.” For Michael, who holds a PhD in aerospace engineering and researches immunology and radio biology, it was an opportunity to experience life as an astronaut doing science in space. “I’ve flown [experiments] on the space station and shuttle,” he said. “Now I wanted to see the other side.” For Will, a geosciences PhD, it provided an opportunity to contribute to space exploration and neuroscience, which he considers two of the biggest fields with the most potential in science. “Here, we have this project that is the perfect intersection of those two things,” he said. And Ellie, a pilot in the Air Force, learned about HERA while working on her master’s thesis on Earth and space analogs and how to improve them for deep-space studies. “A lot of my interests are similar to Chi’s,” she said. “Human factors and physiological aspects are things that I find very fascinating.”

NASA missions all have patches, and HERA Mission XVII is no different. Did you get to design your patch?

Welcome Home HERA Mission XVII!

HERA Mission VXII patch, which reads “May the Force be with you” in Latin and features Star Wars iconography. It’s a reference to the mission’s start date, May 4th aka Star Wars Day!

“We did!” They said …with a little the help from Michael’s brother, who is a designer. He drew several different designs based on the crew’s ideas. They picked one and worked together on tweaks. “We knew we were going [inside the habitat] on May Fourth,” Michael said. “We knew it would be Star Wars Day. So we did a Star Wars theme.” The patch had to come together fairly quickly though, since a Star Wars Day “launch” wasn’t the initial plan. “We were supposed to start two weeks earlier,” Ellie said. “It just so happened the new start date was May the Fourth!” Along with the Star Wars imagery, the patch includes a hurricane symbol, to pay tribute to hurricane Harvey which caused a previous crew to end their mission early, and an image of the HERA habitat. Will joked that designing the patch was “our first team task.”

How much free time did you have and what did you do with it?

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HERA Mission XVII crew looking down the ladders inside the habitat.

“It was a decent amount,” Michael said. “I could have used more on the harder days, but in a way it’s good we didn’t have more because it’s harder to stay awake when you have nothing to do.” (The mission included a sleep reduction study, which meant the crew only got five hours of sleep a night five days a week.) “With the time I did have, I read a lot,” he said. He also drew, kept a journal, and “wrote bad haikus.” Because of the sleep study, Ellie didn’t read as much. “For me, had I tried to read or sit and do anything not interactive, I would have fallen asleep,” she said.

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The crew’s art gallery, where they hung drawing and haikus they wrote.

Journaling and drawing were popular ways to pass the time. “We developed a crew art gallery on one of the walls,” Will said. They also played board games—in particular a game where you score points by making words with lettered tiles on a 15×15 grid. (Yes that one!) “Playing [that game] with two scientists wasn’t always fun though,” Ellie joked, referencing some of the more obscure vocabulary words Will and Michael had at the ready. “I was like, ‘What does that word mean?’ ‘Well that word means lava flow,” she said laughing. (The rest of the crew assured us she fared just fine.)

Chi tried reading, but found it difficult due to the dimmed lights that were part of an onboard light study. She took on a side project instead: 1000 paper cranes. “There is a story in Japan—I’m half Japanese—that if you make a 1000 cranes, it’s supposed to grant you a wish,” she said. She gave hers to her grandmother.

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The whole crew having dinner together on “Sophisticated Saturdays!” From left to right: Will, Ellie, Chi, and Michael. They’re wearing their Saturday best, which includes the usual research equipment.

On weekends, the crew got eight hours of sleep, which they celebrated with “Sophisticated Saturdays!” “Coming in, we all brought an outfit that was a little fancy,” Ellie said. (Like a tie, a vest, an athletic dress—that kind of thing.) “We would only put it on Saturday evenings, and we’d have dinner on the first level at the one and only table we could all sit at and face each other,” she said. “We would pretend it was a different fancy restaurant every week.”

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The table set for a “civilized” Saturday dinner. Once the crew’s hydroponics grew, they were able to add some greenery to the table.

“It was a way to feel more civilized,” Will said, who then offered another great use of their free time: establishing good habits. “I would use the free time to journal, for example. I’d just keep it up every day. That and stretching. Hydrating. Flossing.”

Like real astronauts, you were in contact with Mission Control and further monitored by HERA personnel. Was it weird being on camera all the time?

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HERA personnel and the monitors they use for a typical HERA mission.

“I was always aware of it,” Michael said, “but I don’t think it changed my behavior. It’s not like I forgot about it. It was always there. I just wasn’t willing to live paranoid for 45 days.” Ellie agreed. “It was always in the back of my mind,” she said, further adding that they wore microphones and various other sensors. “We were wired all the time,” she said.

After the study, the crew met up with the people facilitating the experiments, sometimes for the first time. “It was really fun to meet Mission Control afterwards,” Will said. “They had just been this voice coming from the little boxes. It was great getting to meet them and put faces to the voices,” he said. “Of course, they knew us well. Very well.”

For more information on HERA, visit our analogs homepage.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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3 years ago

Ready for a virtual adventure through the Orion Nebula?

Suspended in space, the stars that reside in the Orion Nebula are scattered throughout a dramatic dust-and-gas landscape of plateaus, mountains, and valleys that are reminiscent of the Grand Canyon. This visualization uses visible and infrared views, combining images from the Hubble Space Telescope and the Spitzer Space Telescope to create a three-dimensional visualization.

Learn more about Hubble’s celebration of Nebula November and see new nebula images, here.

You can also keep up with Hubble on Twitter, Instagram, Facebook, and Flickr!

Visualization credits: NASA, ESA, and F. Summers, G. Bacon, Z. Levay, J. DePasquale, L. Hustak, L. Frattare, M. Robberto, M. Gennaro (STScI), R. Hurt (Caltech/IPAC), M. Kornmesser (ESA); Acknowledgement: A. Fujii, R. Gendler


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9 years ago

An Exo-What...?

An Exo-What...?

Simply put, an exoplanet is a planet that orbits another star. That said, just because a planet orbits a star (like Earth) does not mean that it is automatically stable for life. The planet must be within the habitable zone, which is the area around a star in which water has the potential to be liquid…aka not so close that all the water would evaporate, and not too far away where all the water would freeze.

Recently, with the help of our Kepler spacecraft, scientists have discovered the most Earth-like exoplanet ever, Kepler-452b. Pretty cool! This chart shows 12 other exoplanet discoveries that are less than twice the size of Earth, and live in the habitable zone of their host star. Kepler-452b is special because all previous findings have orbited stars that are smaller and cooler than Earth’s.

An Exo-What...?

You may be thinking, “Okay, so what? There’s an Earth-like planet that spins around a similar sized sun.” Well, Kepler-452b orbits its sun at nearly the same distance from its star as Earth does from our sun, which means that conditions on the plant could be similar to those here on Earth!

An Exo-What...?

We can already guess your next question…”When are we going to Kepler-452b?!” Well, this planet is located in the constellation Cygnus which is 1,400 light-years away, so not anytime soon. However, our Kepler spacecraft continues to search for Earth-like exoplanets and gather important scientific information about them.


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