Small Tissue Chips In Space A Big Leap Forward For Research

Small Tissue Chips in Space a Big Leap Forward for Research

Tissue chips, thumb-drive sized devices that contain human cells in a 3D matrix, represent a giant leap in science.

They can test cells’ response to:

•stresses

•drugs

•genetic changes

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The Tissue Chips in Space initiative seeks to better understand the role of microgravity on human health and disease and to translate that understanding to improved human health on Earth.

This series of investigations to test tissue chips in microgravity aboard the International Space Station is planned through a collaboration between the National Center for Advancing Translational Sciences (NCATS) at the National Institutes for Health (NIH) and the National Laboratory in partnership with NASA.

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Many of the changes in the human body caused by microgravity resemble the onset and progression of diseases associated with aging on Earth, but in space, changes occur much faster. Scientists may be able to use tissue chips in space to model changes that take months or years to happen on Earth.

A tissue chip needs three properties, according to Lucie Low, scientific program manager at NCATS. “It has to be 3D,” she explained. “It must have multiple different types of cells, and it must have microfluidic channels. Essentially, you get a functional unit of what human tissues are like, outside of the body,” said Low.

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As accurate models of the structure and function of human organs, tissue chips provide a model for predicting whether a drug, vaccine or biologic agent is safe in humans more quickly and effectively than current methods.

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This first phase of Tissue Chips in Space includes five investigations. An investigation of immune system aging is planned for launch on the SpaceX CRS-16 flight, scheduled for mid-November. The other four, scheduled to launch on subsequent flights, include lung host defense, the blood-brain barrier, musculoskeletal disease and kidney function. This phase tests the effects of microgravity on the tissue chips and demonstrates the capability of the automated system.

All five investigations make a second flight about 18 months later to confirm use of the model, such as testing potential drugs on the particular organs. Four more projects are scheduled for launch in summer 2020, including two on engineered heart tissue to understand cardiovascular health, one on muscle wasting and another on gut inflammation.

Ultimately, the technology could allow astronauts going into space to take along personalized chips that could be used to monitor changes in their bodies and to test possible countermeasures and therapies. That would be a major leap forward in keeping astronauts healthy on missions to deep space!

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9 years ago

SpaceX Dragon: What’s Onboard?

SpaceX is scheduled to launch its Dragon spacecraft into orbit on April 8, which will be the company’s eighth mission under our Commercial Resupply Services contract. This flight will deliver science and supplies to the International Space Station.

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The experiments headed to the orbiting laboratory will help us test the use of an expandable space habitat in microgravity, assess the impact of antibodies on muscle wasting in a microgravity environment, use microgravity to seek insight into the interactions of particle flows at the nanoscale level and use protein crystal growth in microgravity to help in the design of new drugs to fight disease. Here’s an in-depth look at each of them:

The Bigelow Expandable Activity Module (BEAM)

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Space is in limited supply on the International Space Station, but with BEAM, the amount of crew space could be expanded! BEAM is an experimental expandable capsule that attaches to the space station. After installation, it will expand to roughly 13-feet long and 10.5 feet in diameter, which would provide a large volume where a crew member could enter. During the two-year test mission, astronauts will enter the module for a few hours three-to-four times a year to retrieve sensor data and conduct assessments of the module’s condition.

Why? Expandable habitats greatly decrease the amount of transport volume at launch for future space missions. They not only take up less room on a rocket, but also provide greatly enhanced space for living and working once they are set up.

The Rodent Research-3-Eli Lilly

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The Rodent Research-3-Eli Lilly investigation will use mice as a model for human health to study whether certain drugs might prevent muscle or bone loss while in microgravity.

Why? Crew members experience significant decreases in their bone density and muscle mass during spaceflight if they do not get enough exercise during long-duration missions. The results could expand scientist’s understanding of muscle atrophy and bone loss in space, by testing an antibody that has been known to prevent muscle wasting in mice on Earth.

Microbial Observatory-1

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The Microbial Observatory-1 experiment will track and monitor changes to microbial flora over time on the space station.

Why? Obtaining data on these microbial flora could help us understand how such microbes could affect crew health during future long-duration missions.

Micro-10

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The Micro-10 investigation will study how the stress of microgravity triggers changes in growth, gene expression, physical responses and metabolism of a fungus called Aspergillus nidulans.

Why? This experiment will study fungi in space for the purpose of potentially developing new medicine for use both in space and on Earth. The stressfull environment of space causes changes to all forms of life, from bacteria and fungi, to animals and people.

Genes in Space-1

SpaceX Dragon: What’s Onboard?

Genes in Space-1 is a student-designed experiment that will test whether the polymerase chain reaction (PCR) — which is a fast and relatively inexpensive technique that can amplify or “photocopy” small segments of DNA — could be used to study DNA alterations that crew experience during spaceflight.

Why? In space, the human immune system’s function is altered. Findings from this experiment could help combat some of the DNA changes that crew onboard space station experience while on orbit.

Microchannel Diffusion

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Nano science and nanotechnology are the study and application of exceptionally small things and can be used across the fields of medicine, biology, computer science and many others. The way fluid moves is very different on this small scale, so scientists want to know how microparticles might interact. The Microchannel Diffusion investigation simulates these interactions by studying them at a larger scale, the microscopic level. This is only possible on the orbiting laboratory, where Earth’s gravity is not strong enough to interact with the molecules in a sample, so they behave more like they would at the nanoscale.

Why? Nanofluidic sensors could measure the air in the space station, or used to deliver drugs to specific places in the body, among other potential uses. Knowledge learned from this investigation may have implications for drug delivery, particle filtration and future technological applications for space exploration.

The CASIS Protein Crystal Growth 4 (CASIS PCG 4)

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CASIS PCG 4 is made up of two investigations that both leverage the microgravity environment in the growth of protein crystals and focus on structure-based drug design (SBDD). Growing crystals in microgravity avoids some of the obstacles they face on Earth, such as sedimentation.

Why? SBDD is an integral component in the drug discovery and development process. It relies on three-dimensional, structural information provided by the protein crystallography to inform the design of more potent, effective and selective drugs.

Watch the Launch!

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The Dragon capsule will launch on a Falcon 9 rocket from Cape Canaveral Air Force Station in Florida.

Launch coverage begins at 3:15 p.m. EDT, with launch scheduled for 4:43 p.m. Watch live online on NASA Television: nasa.gov/nasatv

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9 years ago

NASA: 2016 Look Ahead

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The work we do, and will continue in 2016, helps the United States maintain its world leadership in space exploration and scientific discovery. Here’s an overview of what we have planned for the coming year:

Our Journey to Mars

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We’re developing the capabilities needed to send humans to an asteroid by 2025 and Mars in the 2030s. Mars is a rich destination for scientific discovery and robotic and human exploration as we expand our presence into the solar system. Its formation and evolution are comparable to Earth, helping us learn more about our own planet’s history and future.

Work and Research on the International Space Station

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The International Space Station is a unique place – a convergence of science, technology and human innovation that demonstrates new technologies and makes research breakthroughs not possible on Earth. In 2016, we will continue our groundbreaking research on the orbiting laboratory.

Returning Human Spaceflight Launches to American Soil

NASA: 2016 Look Ahead

Our Commercial Crew Program is working with the American aerospace industry as companies develop and operate a new generation of spacecraft and launch systems capable of carrying crews to low-Earth orbit and the International Space Station. Commercial transportation to and from the station will provide expanded utility, additional research time and broader opportunities of discovery on the orbiting laboratory.

Studying Our Earth Right Now

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We use the vantage point of space to increase our understanding of our home planet, improve lives and safeguard our future. In 2016, we will continue to monitor Earth’s vital signs from land, air and space with a fleet of satellites and ambitious airborne and ground-based observation campaigns.

Fostering Groundbreaking Technology Development

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Sustained investments in NASA technology advances our space exploration, science and aeronautics capabilities. Our technology development also supports the nation's innovation economy by creating solutions that generate tangible benefits for life on earth. In 2016, we will continue to invest in the future of innovation.

Breakthroughs in Aeronautics

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Thanks to our advancements in aeronautics, today’s aviation industry is better equipped than ever to safely and efficiently transport all those passengers to their destinations. In fact, every U.S. aircraft flying today and every U.S. air traffic control tower uses NASA-developed technology in some way. In 2016, we will continue making these breakthroughs in aeronautics.

Discoveries in Our Solar System and Beyond

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This year we will continue exploring our solar system and beyond to unravel the mysteries of our universe. We are looking to answer key questions about our home planet, neighboring planets in our solar system and more!

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9 years ago

A Wider Set of Eyes on the Universe

After years of preparatory studies, we are formally starting an astrophysics mission designed to help unlock the secrets of the universe. 

Introducing…

the Wide Field Infrared Survey Telescope, aka WFIRST.

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With a view 100 times bigger than that of our Hubble Space Telescope, WFIRST will help unravel the secrets of dark energy and dark matter, and explore the evolution of the cosmos. It will also help us discover new worlds and advance the search for planets suitable for life.

WFIRST is slated to launch in the mid-2020s. The observatory will begin operations after traveling about one million miles from Earth, in a direction directly opposite the sun.

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Telescopes usually come in two different “flavors” - you have really big, powerful telescopes, but those telescopes only see a tiny part of the sky. Or, telescopes are smaller and so they lack that power, but they can see big parts of the sky. WFIRST is the best of worlds.

No matter how good a telescope you build, it’s always going to have some residual errors. WFIRST will be the first time that we’re going to fly an instrument that contains special mirrors that will allow us to correct for errors in the telescope. This has never been done in space before!

Employing multiple techniques, astronomers will also use WFIRST to track how dark energy and dark matter have affected the evolution of our universe. Dark energy is a mysterious, negative pressure that has been speeding up the expansion of the universe. Dark matter is invisible material that makes up most of the matter in our universe.

Single WFIRST images will contain over a million galaxies! We can’t categorize and catalogue those galaxies on our own, which is where citizen science comes in. This allows interested people in the general public to solve scientific problems.

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8 years ago

What is it Like to be a NASA Intern?

We asked prospective interns that follow us on social media what questions they had for our current interns. 

You asked…they answered! Let’s take a look:

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Answer: “Yes, sometimes astronauts request to run through the International Space Station simulation that we have using the hyper-reality lab.”

What Is It Like To Be A NASA Intern?

Answer: “Persistence is the key to getting your first NASA internship. Work hard, study hard, keep applying and persevere.”

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Answer: “NASA is looking for passionate, smart and curious, full-time students, who are U.S. citizens, at least 16 years of age and have a minimum 3.0 GPA.”

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Answer: “In addition to STEM majors, NASA has many opportunities for students studying business, photography, English, graphics and public relations.”

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Answer: “The highlight has been the chance to learn a lot more about embedded systems and coding for them, and just seeing how everyone’s efforts in lab come together for our small part in the AVIRIS-NG project.”

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Answer: Yes! Here at the Kennedy Space Center is where all the action takes place. Check out the schedule on our website!”

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Answer:  “There are 10 NASA field centers and they all accept interns.”

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Answer: "Yes, we do! I am currently working in tech development for an X-ray telescope that is launched into space to take pictures of our galaxy.”

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Answer: “The greatest thing I’ve learned as a NASA intern is to not be afraid of failing and to get involved in any way you can. NASA is a very welcoming environment that offers a lot of opportunities for its interns to learn.”

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Answer: My favorite experience from being a NASA intern is meeting people from all around the world and being exposed to the different cultures.”

Want to become a NASA intern? Visit intern.nasa.gov to learn about the open opportunities and follow @NASAInterns on Twitter and Facebook for regular updates!

Watch the full story on NASA Snapchat or Instagram until it expires on April 6.

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5 years ago

The Rover Doctor is in: The Anatomy of a NASA Human Exploration Rover Challenge Rover

Exploration and inspiration collide head-on in our Human Exploration Rover Challenge held near Marshall Space Flight Center in Huntsville, Alabama, each April. The annual competition challenges student teams from around the world to design, build and drive a human-powered rover over a punishing half-mile course with tasks and obstacles similar to what our astronauts will likely have on missions to the Moon, Mars and beyond.

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The anatomy of the rover is crucial to success. Take a look at a few of the vital systems your rover will need to survive the challenge!

The Chassis

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A rover’s chassis is its skeleton and serves as the framework that all of the other rover systems attach to. The design of that skeleton incorporates many factors: How will your steering and braking work? Will your drivers sit beside each other, front-to-back or will they be offset? How high should they sit? How many wheels will your rover have? All of those decisions dictate the design of your rover’s chassis.

Wheels

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Speaking of wheels, what will yours look like? The Rover Challenge course features slick surfaces, soft dunes, rocky craters and steep hills – meaning your custom-designed wheels must be capable of handling diverse landscapes, just as they would on the Moon and Mars. Carefully cut wood and cardboard, hammer-formed metal and even 3-D printed polymers have all traversed the course in past competitions.

Drivetrain

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You’ve got your chassis design. Your wheels are good to go. Now you have to have a system to transfer the energy from your drivers to the wheels – the drivetrain. A good drivetrain will help ensure your rover crosses the finish line under the 8-minute time limit. Teams are encouraged to innovate and think outside the traditional bike chain-based systems that are often used and often fail. Exploration of the Moon and Mars will require new, robust designs to explore their surfaces. New ratchet systems and geared drivetrains explored the Rover Challenge course in 2019.

Colors and Gear

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Every good rover needs a cool look. Whether you paint it your school colors, fly your country’s flag or decorate it to support those fighting cancer (Lima High School, above, was inspired by those fighting cancer), your rover and your uniform help tell your story to all those watching and cheering you on. Have fun with it!

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Are you ready to conquer the Rover Challenge course? Join us in Huntsville this spring! Rover Challenge registration is open until January 16, 2020 for teams based in the United States.

If building rovers isn’t your space jam, we have other Artemis Challenges that allow you to be a part of the NASA team – check them out here.

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Want to learn about our Artemis program that will land the first woman and next man on the Moon by 2024? Go here to read about how NASA, academia and industry and international partners will use innovative technologies to explore more of the lunar surface than ever before. Through collaborations with our commercial, international and academic partners, we will establish sustainable lunar exploration by 2028, using what we learn to take astronauts to Mars. 

The students competing in our Human Exploration Rover Challenge are paramount to that exploration and will play a vital role in helping NASA and all of humanity explore space like we’ve never done before!

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6 years ago

Experience High-Res Science in First 8K Footage from Space

Fans of science in space can now experience fast-moving footage in even higher definition as NASA delivers the first 8K ultra high definition (UHD) video of astronauts living, working and conducting research from the International Space Station.

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The same engineers who sent high-definition (HD) cameras, 3D cameras, and a camera capable of recording 4K footage to the space station have now delivered a new camera– Helium 8K camera by RED – capable of recording images with four times the resolution than the previous camera offered.

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Let’s compare this camera to others: The Helium 8K camera is capable of shooting at resolutions ranging from conventional HDTV up to 8K, specifically 8192 x 4320 pixels. By comparison, the average HD consumer television displays up to 1920 x 1080 pixels of resolution, and digital cinemas typically project 2K to 4K.

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Viewers can watch as crew members advance DNA sequencing in space with the BEST investigation, study dynamic forces between sediment particles with BCAT-CS, learn about genetic differences in space-grown and Earth-grown plants with Plant Habitat-1, observe low-speed water jets to improve combustion processes within engines with Atomization and explore station facilities such as the MELFI, the Plant Habitat, the Life Support Rack, the JEM Airlock and the CanadArm2.

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Delivered to the station aboard the fourteenth SpaceX cargo resupply mission through a Space Act Agreement between NASA and RED, this camera’s ability to record twice the pixels and at resolutions four times higher than the 4K camera brings science in orbit into the homes, laboratories and classrooms of everyone on Earth. 

While the 8K resolutions are optimal for showing on movie screens, NASA video editors are working on space station footage for public viewing on YouTube. Viewers will be able to watch high-resolution footage from inside and outside the orbiting laboratory right on their computer screens. Viewers will need a screen capable of displaying 8K resolution for the full effect, but the imagery still trumps that of standard cameras. RED videos and pictures are shot at a higher fidelity and then down-converted, meaning much more information is captured in the images, which results in higher-quality playback, even if viewers don't have an 8K screen.   

The full UHD files are available for download for use in broadcast. Read the NASA media usage guidelines. 


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8 years ago

More Than Just Drawings

Artist and graphic designer Mike Okuda may not be a household name, but you’re more familiar with his work than you know. Okuda’s artistic vision has left a mark here at NASA and on Star Trek. The series debuted 50 years ago in September 1966 and the distinctive lines and shapes of logos and ships that he created have etched their way into the minds of fans and inspired many.  

Flight Ops

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The Flight Operations patch has a lengthy history, the original version of which dates to the early 1970s. Having designed a version of the patch, Okuda had some insights about the evolution of the design.

“The original version of that emblem was designed around 1972 by Robert McCall and represented Mission Control. It later changed to Mission Operations. I did the 2004 version, incorporating the space station, and reflecting the long-term goals of returning to the Moon, then on to Mars and beyond. I later did a version intended to reflect the new generation of spacecraft that are succeeding the shuttle, and most recently the 2014 version reflecting the merger of Mission Operations with the Astronaut Office under the new banner Flight Operations.”

“The NASA logos and patches are an important part of NASA culture,” Okuda said. “They create a team identity and they focus pride on a mission.”

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In July 2009, Okuda received the NASA Exceptional Public Service Medal, which is awarded to those who are not government employees, but have made exceptional contributions to NASA’s mission. Above, Okuda holds one of the mission patches he designed, this one for STS-125, the final servicing mission to the Hubble Space Telescope.

Orion

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Among the other patches that Okuda has designed for us, it one for the Orion crew exploration vehicle. Orion is an integral of our Journey to Mars and is an advanced spacecraft that will take our astronauts deeper into the solar system than ever before. 

Okuda’s vision of space can be seen in the Star Trek series through his futuristic set designs, a vision that came from his childhood fascination with the space program. 

Learn more about Star Trek and NASA.

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6 years ago

We Found the Universe’s First Type of Molecule

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For decades, astronomers searched the cosmos for what is thought to be the first kind of molecule to have formed after the Big Bang. Now, it has finally been found. The molecule is called helium hydride. It’s made of a combination of hydrogen and helium. Astronomers think the molecule appeared more than 13 billion years ago and was the beginning step in the evolution of the universe. Only a few kinds of atoms existed when the universe was very young. Over time, the universe transformed from a primordial soup of simple molecules to the complex place it is today — filled with a seemingly infinite number of planets, stars and galaxies. Using SOFIA, the world’s largest airborne observatory, scientists detected newly formed helium hydride in a planetary nebula 3,000 light-years away. It was the first ever detection of the molecule in the modern universe. Learn more about the discovery:

Helium hydride is created when hydrogen and helium combine. 

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Since the 1970s, scientists thought planetary nebula NGC 7027—a giant cloud of gas and dust in the constellation Cygnus—had the right environment for helium hydride to exist. 

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But space telescopes could not pick out its chemical signal from a medley of molecules. 

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Enter SOFIA, the world’s largest flying observatory! 

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By pointing the aircraft’s 106-inch telescope at the planetary nebula and using a tool that works like a radio receiver to tune in to the “frequency” of helium hydride, similar to tuning a radio to a favorite station…

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…the molecule’s chemical signal came through loud and clear, bringing a decades-long search to a happy end.

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The discovery serves as proof that helium hydride can, in fact, exist in space. This confirms a key part of our basic understanding of the chemistry of the early universe. SOFIA is a modified Boeing 747SP aircraft that allows astronomers to study the solar system and beyond in ways that are not possible with ground-based telescopes. Find out more about the mission at www.nasa.gov/SOFIA

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9 years ago

A Q&A from the Space Station!

Did you miss it? Astronaut Scott Kelly answered questions over the weekend on People Magazine’s Facebook page! Anything and everything from his favorite food in space to his year aboard the International Space Station. 

Here are a few highlights from the conversation:

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Follow Astronaut Scott Kelly during the remainder of his year in space: Facebook, Twitter, Instagram

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2 years ago

A Laboratory for Star Formation

Alt text: In this image of NGC 3603, a bright cluster of stars shining in red, orange, and yellow hues dominates the center. The stars become more sporadic throughout the rest of the image, glittering against a black backdrop of space and nebulous indigo clouds that glow in the picture’s lower half.

Credit: NASA, ESA, R. O'Connell (University of Virginia), F. Paresce (National Institute for Astrophysics, Bologna, Italy), E. Young (Universities Space Research Association/Ames Research Center), the WFC3 Science Oversight Committee, and the Hubble Heritage Team (STScI/AURA)

Location: In the Carina spiral arm of our Milky Way Galaxy

Distance from Earth: About 20,000 light-years

Object type: Nebula and open star cluster

Discovered by: Sir John Herschel in 1834

Imaged here by the Hubble Space Telescope, NGC 3603 is a collection of thousands of large, hot stars, including some of the most massive stars known to us. Scientists categorize it as an “open cluster” because of its spread-out shape and low density of stars. Surrounding the bright star cluster are plumes of interstellar gas and dust, which comprise the nebula part of this cosmic object. New stars are formed from the gaseous material within these clouds! NGC 3603 holds stars at a variety of life stages, making it a laboratory for scientists to study star evolution and formation. Astronomers estimate that star formation in and around the cluster has been occurring for 10 to 20 million years.

Read more information about NGC 3603 here.

Right now, the Hubble Space Telescope is delving into its #StarrySights campaign! Find more star cluster content and breathtaking new images by following along on Hubble’s Twitter, Facebook, and Instagram.

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