Ja Ja Ja Ja Ja

“And we laugh like soft mad children, mug in the woolly cotton brains of infancy ...”

Camino con pasos descompuestos y una quietud desagradable, quedándome mirando horizontes de una lejana tranquilidad.

immarcescibilis (via biblioteca-prohibida)

Desempolvando recuerdos y sin dejar rastro en este mundo. Me descompongo, me pierdo...

Study Looks for DNA Changes to Measure Parkinson’s Disease

Neurons derived from a patient with Parkinson’s disease. Courtesy of Regis Grailhe, Nasia Antoniou and Rebecca Matsas, Institut Pasteur Korea/Nikon Small World.

Researchers at University of California San Diego School of Medicine and Arizona State University (ASU) have received funding from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to launch a multi-year, $1.7-million effort to identify blood-based biomarkers of Parkinson’s disease (PD), which could improve care and accelerate new treatments for the neurodegenerative disorder, which affects nearly 1 million Americans, with 60,000 new cases diagnosed annually.

“The exact cause of Parkinson’s is unknown, but evidence points to a combination of genetic and environmental factors. Right now, there is no objective test or biomarker for PD, which increases the risk of misdiagnosis and delayed treatment,” said Paula Desplats, PhD, assistant professor in the Department of Neurosciences at UC San Diego School of Medicine and co-principal investigator of the new study with Travis Dunckley, PhD, assistant research professor at ASU’s Biodesign Institute.

The new study will analyze nearly 2,500 blood samples collected longitudinally over three years in the MJFF-sponsored Parkinson’s Progression Markers Initiative (PPMI). These samples include donations from patients diagnosed with idiopathic (cause unknown) PD; PD patients and asymptomatic individuals who carry a genetic mutation in the PD-implicated LRKK2 gene; at-risk populations of people with REM sleep behavior disorder and/or smell loss; as well as healthy control subjects. Researchers will analyze DNA methylation, an epigenetic modification of the DNA that can change genetic activity without changing the underlying sequence. DNA methylation is critical to turning genes on and off and affects a vast range of cellular functions and fundamental development.

“This epigenetic analysis could help us better understand the pathology of Parkinson’s disease, pointing to biomarker candidates and, potentially, novel therapeutic targets,” said Samantha Hutten, PhD, MJFF senior associate director of research partnerships. “In addition, this DNA methylation data grows the value of the PPMI clinical, imaging and biological database, the most robust in Parkinson’s research.”

“Study Looks for DNA Changes to Measure Parkinson’s Disease“

deje de pelearse con su cuerpo porque la única persona que va a salir perdiendo es usted

Porque te he dicho adiós cientos deveces de un portazo, y regreso ciento un veces con la cabeza gacha y al reposarme sobre tu hombro dices: «te lo dije» porque incluso quise quemar todas aquellas cosas sin darme cuenta de que, aún si lo hiciera, seguiría amándolas. —sé que me comporté como una tonta— porque me hice creer que no eras para mí y ahora que lo comprendo creo que nunca debí decidir algo cuando estaba de malas, y más si he renacido de ti. Sé que debo pedirte perdón, porque me conoces como nadie y me brindas calidez como a todos —o al menos a quien sale a buscarte— porque hay algo que sé con certeza, y es que quien se arropa de ti, amada ciencia, probablemente nunca tira de tu sábana y se va. Y yo soy una prueba viviente de ello.  https://www.instagram.com/p/BwN-YEbhk1g/?utm_source=ig_tumblr_share&igshid=1jf3d71jytl2n

Mihály Kovács, Portrait of a Couple (Wife) (1852)

Estoy un poco lastimado pero no estoy muerto. Me recostaré para sangrar un rato. Luego me levantaré a pelear de nuevo.

John Dryden

Todo esto es una mierda, estoy enamorada de la idea del amor, mi cerebro solamente se siente bien si cree en el enamoramiento o esos sentimientos que se supone debemos de tener por otras personas. Pero él me tiene aquí escribiendo, ansiosa… Triste… Y necesitada de su jodida atención.

(via poetamundo)

“Creo en los cafés, en el dialogo, creo en la dignidad de la persona, en la libertad. Siento nostalgia, casi ansiedad en el infinito, pero humano, a nuestra medida.”

- Ernesto Sábato.