Thedevilpriv-blog - De Todo El Mundo

Agnes Obel - The Curse (Berlin Live Session)

Volcano Rabbit Romerolagus diazi Sources: 1, 2, 3

En la sombra del otro buscamos nuestra sombra; en el cristal del otro, nuestro cristal recíproco.

Jorge Luis Borges

Study Looks for DNA Changes to Measure Parkinson’s Disease

Neurons derived from a patient with Parkinson’s disease. Courtesy of Regis Grailhe, Nasia Antoniou and Rebecca Matsas, Institut Pasteur Korea/Nikon Small World.

Researchers at University of California San Diego School of Medicine and Arizona State University (ASU) have received funding from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to launch a multi-year, $1.7-million effort to identify blood-based biomarkers of Parkinson’s disease (PD), which could improve care and accelerate new treatments for the neurodegenerative disorder, which affects nearly 1 million Americans, with 60,000 new cases diagnosed annually.

“The exact cause of Parkinson’s is unknown, but evidence points to a combination of genetic and environmental factors. Right now, there is no objective test or biomarker for PD, which increases the risk of misdiagnosis and delayed treatment,” said Paula Desplats, PhD, assistant professor in the Department of Neurosciences at UC San Diego School of Medicine and co-principal investigator of the new study with Travis Dunckley, PhD, assistant research professor at ASU’s Biodesign Institute.

The new study will analyze nearly 2,500 blood samples collected longitudinally over three years in the MJFF-sponsored Parkinson’s Progression Markers Initiative (PPMI). These samples include donations from patients diagnosed with idiopathic (cause unknown) PD; PD patients and asymptomatic individuals who carry a genetic mutation in the PD-implicated LRKK2 gene; at-risk populations of people with REM sleep behavior disorder and/or smell loss; as well as healthy control subjects. Researchers will analyze DNA methylation, an epigenetic modification of the DNA that can change genetic activity without changing the underlying sequence. DNA methylation is critical to turning genes on and off and affects a vast range of cellular functions and fundamental development.

“This epigenetic analysis could help us better understand the pathology of Parkinson’s disease, pointing to biomarker candidates and, potentially, novel therapeutic targets,” said Samantha Hutten, PhD, MJFF senior associate director of research partnerships. “In addition, this DNA methylation data grows the value of the PPMI clinical, imaging and biological database, the most robust in Parkinson’s research.”

“Study Looks for DNA Changes to Measure Parkinson’s Disease“

“Estos retratos son mi corazón. Y si mi corazón fuera un lienzo, cada centímetro cuadrado sería un dibujo tuyo.”

— “Lady Midnight. Cazadores de sombras: Renacimiento” de Cassandra Clare (via miscitasliterarias)

“Eran alrededor de las diez de la noche. La luna estaba alta y mi vida iba lentamente hacia ningún lado.”

— Charles Bukowski, Pulp (via elcielosobremi)

Did you know that there’s more to Saint Valentine than Valentine’s Day, romance, and love? He’s also the patron saint of beekeepers - charged with ensuring the sweetness of honey and the protection of beekeepers. 🐝💕 These little bees are now available in my shop along with a few other new sweet treats! 💝 Link in my profile 💞

#tracylewisart #watercolor #pink #bees #beekeeper #stvalentine http://bit.ly/2Soyj7h

“25 de enero 2017 No me puedo ir a dormir sin decirte que alegras mi vida a cada momento… Luz de mis días. Qué jamás me falte tu risa perfecta, la paz de tu mirada, tus cálidas manos, la forma de tu boca, tu andar distraído, tus piernas delgadas, tu cabello rebelde, la música de tu voz… Debes saber que eres lo más bello que existe y que es hermoso poder mirarte, tocarte, refugiarme en tus brazos cuando hay miedo… Te quiero, te quieren mis huesos, mi carne, mi alma, mi mente, mi corazón… No te vayas ésta noche, no te vayas nunca… Quiero verte cada día al despertar”

— Letras Secretas (via letrassecretas)

“Hay personas que juntas hacen magia, y separadas sólo desastres. Personas que juntas son poesía, y separadas puro cuento. Y hay personas que juntas detienen el tiempo, y separas sólo alargan los años”

— Brenda Ramírez. (via biblioteca-prohibida)

Le llamé para escuchar de su voz que era el final, definitivamente no quería quedarme con el recuerdo de su voz diciendo "Buenas noches, Pili. Te amo." Que interesante cambian las cosas en un par de minutos...