Déjame Un Rato Aquí, Tirado En La Cama Que Me Duele Un Poco El Alma

¿Cuánto daño te hizo aquel hijo de puta para qué pienses que estar sola es un bienestar?   ¿Cuánto daño te hizo aquel hijo de puta para qué sueñes con lo que no fue y no con lo que será?   ¿Cuánto daño te hizo aquel hijo de puta para qué pienses que fuiste la culpable de terminar?   ¿Cuánto daño te hizo aquel hijo de puta para que creas que eres una puta niña rara y no lo más bonito de este mundo sideral?   ¿Cuánto daño te hizo aquel hijo de puta para que no puedas gemir mi nombre cuando llegas al clímax?   Dime…

¿Cuánto daño te hizo aquel hijo de puta para que llores y sangres en cada poesía que escribes recordando mi nombre?

— Manuel Ignacio.

No cortes el lazo. Aguanta otro poco más. No estoy listo para que te vayas aún.

— erickknox

Me, and the Leprechaun and what happened in the clouds.

I met a Leprechaun at the rainbow’s end, he was sitting on his pot of gold, all dressed in a green, and golden blend, he looked so sad; not brave and bold. I snatched the gold from beneath his arse, I was sure he would scream and rave, I was dreaming of champaigne and cars, But he stopped me dead, with the sobs he made.  I sat beside him on the fluffy cloud, and I asked him what was troubling him, he wiped his tears, then spoke aloud, and the tale he told, was sad and grim. Mrs Leprechaun, had been gone for days, he had searched for her,and he feared the worst, it was not like her; she had settled ways, now he blamed her missing, on the Goblin’s curse. “ Come on “, says I, “ we’ll find your love, I’ll not  leave your side ‘til she’s safe back home “,  and we walked for miles on the clouds above, until the sun, no longer shone. He magic’d  up a jug of grog, it was hot as lava; it burned like hell, when from out of the swirling, misty fog, a booming voice, his name did yell. She knocked the hat from off his head, she tore gold buttons, from his shirt of green, she said she thought that he was dead, while all this time, he drank poteen*. I left them to their argument, and went off to find some place to sleep, I dreamed of gold that was heaven sent, but for that gold, I did not weep. * poteen: Irish moonshine.   Ambrose Harte    Scattered Thoughts  

Study Looks for DNA Changes to Measure Parkinson’s Disease

Neurons derived from a patient with Parkinson’s disease. Courtesy of Regis Grailhe, Nasia Antoniou and Rebecca Matsas, Institut Pasteur Korea/Nikon Small World.

Researchers at University of California San Diego School of Medicine and Arizona State University (ASU) have received funding from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to launch a multi-year, $1.7-million effort to identify blood-based biomarkers of Parkinson’s disease (PD), which could improve care and accelerate new treatments for the neurodegenerative disorder, which affects nearly 1 million Americans, with 60,000 new cases diagnosed annually.

“The exact cause of Parkinson’s is unknown, but evidence points to a combination of genetic and environmental factors. Right now, there is no objective test or biomarker for PD, which increases the risk of misdiagnosis and delayed treatment,” said Paula Desplats, PhD, assistant professor in the Department of Neurosciences at UC San Diego School of Medicine and co-principal investigator of the new study with Travis Dunckley, PhD, assistant research professor at ASU’s Biodesign Institute.

The new study will analyze nearly 2,500 blood samples collected longitudinally over three years in the MJFF-sponsored Parkinson’s Progression Markers Initiative (PPMI). These samples include donations from patients diagnosed with idiopathic (cause unknown) PD; PD patients and asymptomatic individuals who carry a genetic mutation in the PD-implicated LRKK2 gene; at-risk populations of people with REM sleep behavior disorder and/or smell loss; as well as healthy control subjects. Researchers will analyze DNA methylation, an epigenetic modification of the DNA that can change genetic activity without changing the underlying sequence. DNA methylation is critical to turning genes on and off and affects a vast range of cellular functions and fundamental development.

“This epigenetic analysis could help us better understand the pathology of Parkinson’s disease, pointing to biomarker candidates and, potentially, novel therapeutic targets,” said Samantha Hutten, PhD, MJFF senior associate director of research partnerships. “In addition, this DNA methylation data grows the value of the PPMI clinical, imaging and biological database, the most robust in Parkinson’s research.”

“Study Looks for DNA Changes to Measure Parkinson’s Disease“

“No, no hay nada que yo no haría, para hacerte sentir mi amor”

Están las chicas como tú que traen un chingo de constelaciones en los párpados y la orilla de las mejillas esas chicas que cuando aman su energía embellece su mirada y su boca es un constante carrusel de sueños Están las chicas como tú que leen y traen un diario escriben bonito y te imaginas perversos encuentros y charlas profundas Están las chicas como tú que cuando les dicen un poema parece que les salen pájaros de los ojitos y su cuerpo tiembla con el eco de una palabra precisa Están las chicas como tú que beben un chingo y en la mañana se ven hermosamente confundidas con las cicatrices visibles pero ya muy cerradas Están las chicas como tú curiosas y un poco torpes abrazables y deseables esas chicas deshechas que toman actitudes bien pendejas cuando alguien no sabe tratarlas con indiferencia

“Trata de no pensar mucho las cosas, todo va a estar bien.”

— SuspirosAlAire

Siento que no estás lejos, estoy llena de ti.

Elena Poniatowska