All About That (Nucleic) Base

All About That (Nucleic) Base

Studying DNA Aboard the International Space Station

What do astronauts, microbes and plants all have in common? Each relies on DNA – essentially a computer code for living things – to grow and thrive. The microscopic size of DNA, however, can create some big challenges for studying it aboard the International Space Station.

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The real question about DNA in space: but why, tho?

Studying DNA in space could lead to a better understanding of microgravity’s impact on living organisms and could also offer ways to identify unknown microbes in spacecraft, humans and the deep space locations we hope to visit one day.

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Most Earth-based molecular research equipment is large and requires significant amounts of power to run. Those are two characteristics that can be difficult to support aboard the station, so previous research samples requiring DNA amplification and sequencing had to be stored in space until they could be sent back to Earth aboard a cargo spacecraft, adding to the time required to get results.

Fun science pro tip: amplification means to make lots and lots of copies of a specific section of DNA.

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However, all of that has changed in a few short years as we’ve worked to find new solutions for rapid in-flight molecular testing aboard the space station.

“We need[ed] to get machines to be compact, portable, robust, and independent of much power generation to allow for more agile testing in space,” NASA astronaut and molecular biologist Kate Rubins said in a 2016 downlink with the National Institutes of Health.

The result? An advanced suite of tabletop and palm-sized tools including MinION, miniPCR, and Wet-Lab-2, and more tools and processes on the horizon.

The timeline:

Space-based DNA testing took off in 2016 with the Biomolecule Sequencer.

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Comprised of the MinION sequencer and a Surface Pro 3 tablet for analysis, the tool was used to sequence DNA in space for the first time with Rubins at the helm.

In 2017, that tool was used again for Genes in Space-3, as NASA astronaut Peggy Whitson collected and tested samples of microbial growth from around the station.

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Alongside MinION, astronauts also tested miniPCR, a thermal cycler used to perform the polymerase chain reaction. Together these platforms provided the identification of unknown station microbes for the first time EVER from space.

This year, those testing capabilities translated into an even stronger portfolio of DNA-focused research for the orbiting laboratory’s fast-paced science schedule. For example, miniPCR is being used to test weakened immune systems and DNA alterations as part of a student-designed investigation known as Genes in Space-5.

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The study hopes to reveal more about astronaut health and potential stress-related changes to DNA created by spaceflight. Additionally, WetLab-2 facility is a suite of tools aboard the station designed to process biological samples for real-time gene expression analysis.

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More tools for filling out the complete molecular studies opportunities on the orbiting laboratory are heading to space soon.

“The mini revolution has begun,” said Sarah Wallace, our principal investigator for the upcoming Biomolecule Extraction and Sequencing Technology (BEST) investigation. “These are very small, efficient tools. We have a nicely equipped molecular lab on station and devices ideally sized for spaceflight.”

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BEST is scheduled to launch to the station later this spring and will compare swab-to-sequencer testing of unknown microbes aboard the space station against current culture-based methods.

Fast, reliable sequencing and identification processes could keep explorers safer on missions into deep space. On Earth, these technologies may make genetic research more accessible, affordable and mobile.

To learn more about the science happening aboard the space station, follow @ISS_Research for daily updates. For opportunities to see the space station pass over your town, check out Spot the Station.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

More Posts from Nasa and Others

5 years ago

Watch Mercury Transit the Sun on Nov. 11

On Nov. 11, Earthlings will be treated to a rare cosmic event — a Mercury transit.

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For about five and a half hours on Monday, Nov. 11 — from about 7:35 a.m. EST to 1:04 p.m. EST — Mercury will be visible from Earth as a tiny black dot crawling across the face of the Sun. This is a transit and it happens when Mercury lines up just right between the Sun and Earth.

Mercury transits happen about 13 times a century. Though it takes Mercury only about 88 days to zip around the Sun, its orbit is tilted, so it's relatively rare for the Sun, Mercury and Earth to line up perfectly. The next Mercury transit isn't until 2032 — and in the U.S., the next opportunity to catch a Mercury transit is in 2049!

How to watch

Our Solar Dynamics Observatory satellite, or SDO, will provide near-real time views of the transit. SDO keeps a constant eye on the Sun from its position in orbit around Earth to monitor and study the Sun's changes, putting it in the front row for many eclipses and transits.

Visit mercurytransit.gsfc.nasa.gov to tune in!

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Our Solar Dynamics Observatory also saw Mercury transit the Sun in 2016.

If you're thinking of watching the transit from the ground, keep in mind that it is never safe to look directly at the Sun. Even with solar viewing glasses, Mercury is too small to be easily seen with the unaided eye. Your local astronomy club may have an opportunity to see the transit using specialized, properly-filtered solar telescopes — but remember that you cannot use a regular telescope or binoculars in conjunction with solar viewing glasses.

Transits in other star systems

Transiting planets outside our solar system are a key part of how we look for exoplanets.

Our Transiting Exoplanet Survey Satellite, or TESS, is NASA’s latest planet-hunter, observing the sky for new worlds in our cosmic neighborhood. TESS searches for these exoplanets, planets orbiting other stars, by using its four cameras to scan nearly the whole sky one section at a time. It monitors the brightness of stars for periodic dips caused by planets transiting those stars.

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This is similar to Mercury’s transit across the Sun, but light-years away in other solar systems! So far, TESS has discovered 29 confirmed exoplanets using transits — with over 1,000 more candidates being studied by scientists!

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Discover more transit and eclipse science at nasa.gov/transit, and tune in on Monday, Nov. 11, at mercurytransit.gsfc.nasa.gov.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.


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3 years ago

Lasers Bring Internet Speeds to Space

Pew. Pew. Lasers in space!

Iconic movie franchises like Star Wars and Star Trek feature futuristic laser technologies, but space lasers aren’t limited to the realm of science fiction. In fact, laser communications technologies are changing the way missions transmit their data. The Laser Communications Relay Demonstration (LCRD) blasts into space this weekend, demonstrating the unique – and totally awesome – capabilities of laser communications systems.

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Currently, NASA missions rely on radio frequency to send data to Earth. While radio has served the agency well since the earliest days of spaceflight, there are significant benefits to laser systems. Just as the internet has gone from dial-up to high-speed connections, lasers communications’ higher frequency allows missions to send much more information per second than radio systems. With laser communications, it would only take nine days to transmit a complete map of Mars back to Earth, compared to nine weeks with radio frequency systems.

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LCRD will demonstrate these enhanced capabilities from 22,000 miles above Earth’s surface. And although the mission uses lasers, these lasers are not visible to the human eye. Once in orbit, the mission will perform experiments using two telescopes on Earth that will relay data through the spacecraft from one site to the other over an optical communications link. These experiments will help NASA and the aerospace community understand the operational challenges of using lasers to communicate to and from space.

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On Earth, there are ground stations telescopes that will capture LCRD’s laser signal and send the data to the mission operations center in New Mexico. The two ground stations are located on Haleakalā, Hawaii and Table Mountain, California. These picturesque locations weren’t chosen because they’re beautiful, but rather for their mostly clear skies. Clouds – and other atmospheric disturbances – can disrupt laser signals. However, when those locations do get cloudy, we’ve developed corrective technologies to ensure we receive and successfully decode signals from LCRD.

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This demonstration will help NASA, researchers, and space companies learn more about potential future applications for laser communications technologies. In the next few years, NASA will launch additional laser missions to the Moon on Artemis II and to the asteroid belt, even deeper into space. These missions will give us insight on the use of laser communications further in space than ever before.

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Ultimately, laser systems will allow us to glean more information from space. This means more galaxy pics, videos of deep space phenomena, and live, 4K videos from astronauts living and working in space.

Laser communications = more data in less time = more discoveries.

If laser communications interests you, check out our Space Communications and Navigation (SCaN) Internship Project. This program provides high school, undergrad, graduate, and even Ph.D. candidates with internship opportunities in space communications areas – like laser comm.

Make sure to follow us on Tumblr for your regular dose of space!


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9 years ago

5 Signs You Might Be Ready to Apply to be an Astronaut

Did you hear? Astronaut applications are open! Here are a few signs that might mean you’re ready to apply:

1. You Don’t Mind Having Roommates

5 Signs You Might Be Ready To Apply To Be An Astronaut

When you’re an astronaut, you have to work and live with your crew mates for extended periods of time. It’s important to the mission and your safety that everyone can collaborate and work together.

2. You LOVE Space

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If the Milky Way, planets and space travel doesn’t excite you then this might not be the perfect job for you. But if you love galaxies, space station research and deep space exploration, then maybe you should take a look at our application.

3. Adventure Doesn’t Scare You

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Being an astronaut means that you get to take part in adventures that most people will never experience. Imagine: sitting on the launch pad in the Orion spacecraft, atop a rocket that’s getting ready to launch. You’ll travel farther into space than any other humans have been and help push the boundaries of technology in the proving ground of deep space lunar orbits, leading the way for future missions to Mars.

4. You Want to be on the Cutting Edge of Science

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Not only do astronauts get to travel to space, but they also get to conduct really cool research in microgravity. Did you know that right now they’re growing Zinnia flowers on the International Space Station? This research could help with our future deep space exploration and could teach us a few things about growing plants on Earth. Learn more about all the awesome research on the space station HERE.

5. You’re Not Afraid of Heights

5 Signs You Might Be Ready To Apply To Be An Astronaut

One of the coolest things about being an astronaut, is that you get to go to SPACE! At the very least, you’ll travel to the International Space Station, which is 250 miles above Earth. Or, you could be one of the first astronauts to travel to a distant asteroid or even Mars!

Interested in applying to become an astronaut? You’re in luck, applications open Dec. 14! Learn about some common myths about becoming an astronaut HERE.

Apply to be one of our astronauts HERE.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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1 year ago

Hello! I am an avid lover of the cosmos and all things too grand for our minds to grasp. I was wondering, honestly, how do you cope with the pressure of your jobs, or say the scale of what is on your shoulders? It's quite an impressive thing you do, and it just gets me curious as to how you deal with the expectations that come with this type of job? Like, when you go home at night and eat your dinner, go to bed, do you have to practice mindfulness? Thanks for answering these! Love you guys!!!


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7 years ago

Five Eclipses in NASA History

On Monday, August 21, 2017, people in North America will have the chance to see an eclipse of the Sun. Anyone within the path of totality may see one of nature’s most awe-inspiring sights – a total solar eclipse. 

Along this path, the Moon will completely cover the Sun, revealing the Sun’s tenuous atmosphere, the corona. The path of totality will stretch from Salem, Oregon, to Charleston, South Carolina. Observers outside this path will still see a partial solar eclipse, where the Moon covers part of the Sun’s disk. Remember: you can never look at the Sun directly, and an eclipse is no exception – be sure to use a solar filter or indirect viewing method to watch partial phases of the eclipse.

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Total solar eclipses are a rare chance to study the Sun and Earth in unique ways. During the total eclipse, scientists can observe the faintest regions of the Sun, as well as study the Sun’s effects on Earth’s upper atmosphere. We’ve been using eclipses to learn more about our solar system for more than 50 years. Let’s take a look back at five notable eclipses of the past five decades.

May 30, 1965

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A total eclipse crossed the Pacific Ocean on May 30, 1965, starting near the northern tip of New Zealand and ending in Peru. Totality – when the Moon blocks all of the Sun’s face – lasted for 5 minutes and 15 seconds at peak, making this the 3rd-longest solar eclipse totality in the 20th century. Mexico and parts of the Southwestern United States saw a partial solar eclipse, meaning the Moon only blocked part of the Sun. We sent scientists to the path of totality, stationing researchers on South Pacific islands to study the response of the upper atmosphere and ionosphere to the eclipse. 

Additionally, our high-flying jets, scientific balloons, and sounding rockets – suborbital research rockets that fly and collect data for only a few minutes – recorded data in different parts of the atmosphere. A Convair 990 research jet chased the Moon’s shadow as it crossed Earth’s surface, extending totality up to more than nine minutes, and giving scientists aboard more time to collect data. A NASA-funded team of researchers will use the same tactic with two jets to extend totality to more than 7 minutes on Aug. 21, 2017, up from the 2 minutes and 40 seconds observable on the ground. 

March 7, 1970

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The total solar eclipse of March 7, 1970, was visible in North America and the northwestern part of South America, with totality stretching to 3 minutes and 28 seconds at maximum. This was the first time a total eclipse in the United States passed over a permanent rocket launch facility – NASA’s Wallops Station (now Wallops Flight Facility) on the coast of Virginia. This eclipse offered scientists from NASA, four universities and seven other research organizations a unique way to conduct meteorology, ionospheric and solar physics experiments using 32 sounding rockets. 

Also during this eclipse, the Space Electric Propulsion Test, or SERT, mission temporarily shut down because of the lack of sunlight. The experimental spacecraft was unable to restart for two days.

July 10, 1972

Five Eclipses In NASA History

Two years later, North America saw another total solar eclipse. This time, totality lasted 2 minutes and 36 seconds at the longest. A pair of scientists from Marshall Space Flight Center in Huntsville, Alabama, traveled to the Canadian tundra to study the eclipse – specifically, a phenomenon called shadow bands. These are among the most ephemeral phenomena that observers see during the few minutes before and after a total solar eclipse. They appear as a multitude of faint rapidly moving bands that can be seen against a white background, such as a large piece of paper on the ground. 

While the details of what causes the bands are not completely understood, the simplest explanation is that they arise from atmospheric turbulence. When light rays pass through eddies in the atmosphere, they are refracted, creating shadow bands.

February 26, 1979

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The last total solar eclipse of the 20th century in the contiguous United States was in early 1979. Totality lasted for a maximum of 2 minutes 49 seconds, and the total eclipse was visible on a narrow path stretching from the Pacific Northwest to Greenland. Agencies from Canada and the United States – including NASA – joined forces to build a sounding rocket program to study the atmosphere and ionosphere during the eclipse by observing particles on the edge of space as the Sun’s radiation was suddenly blocked.

July 31, 1981

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The USSR got a great view of the Moon passing in front of the Sun in the summer of 1981, with totality lasting just over 2 minutes at maximum. Our scientists partnered with Hawaiian and British researchers to study the Sun’s atmosphere – specifically, a relatively thin region called the chromosphere, which is sandwiched between the Sun’s visible surface and the corona – using an infrared telescope aboard the Kuiper Airborne Observatory. The chromosphere appears as the red rim of the solar disk during a total solar eclipse, whereas the corona has no discernible color to the naked eye.

Watch an Eclipse: August 21, 2017 

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On August 21, a total solar eclipse will cross the continental United States from coast to coast for the first time in 99 years, and you can watch.

If skies are clear, people in North America will be able to see a partial or total solar eclipse. Find out what the eclipse will look like in your area, then make sure you have a safe method to watch – like solar viewing glasses or a pinhole projector – and head outside. 

You can also tune into nasa.gov/eclipselive throughout the day on Aug. 21 to see the eclipse like you’ve never seen it before – including a NASA TV show, views from our spacecraft, aircraft, and more than 50 high-altitude balloons.

Get all your eclipse information at https://eclipse2017.nasa.gov/, and follow along with @NASASun on Twitter and NASA Sun Science on Facebook.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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6 years ago

Our Sun is More than Meets the Eye

The Sun may look unchanging to us here on Earth, but that’s not the whole story.

In visible light – the light our eyes can see – the Sun looks like an almost featureless orange disk, peppered with the occasional sunspot. (Important note: Never look at the Sun directly, and always use a proper filter for solar viewing – or tune in to our near-real time satellite feeds!)

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But in other kinds of light, it’s a different picture. The Sun emits light across the electromagnetic spectrum, including the relatively narrow range of light we can see, as well as wavelengths that are invisible to our eyes. Different wavelengths convey information about different components of the Sun’s surface and atmosphere, so watching the Sun in multiple types of light helps us paint a fuller picture.

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Watching the Sun in these wavelengths reveals how active it truly is. This image, captured in a wavelength of extreme ultraviolet light at 131 Angstroms, shows a solar flare. Solar flares are intense bursts of light radiation caused by magnetic events on the Sun, and often associated with sunspots. The light radiation from solar flares can disturb part of Earth’s atmosphere where radio signals travel, causing short-lived problems with communications systems and GPS.

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Looking at the Sun in extreme ultraviolet light also reveals structures like coronal loops (magnetic loops traced out by charged particles spinning along magnetic field lines)…

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…solar prominence eruptions…

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…and coronal holes (magnetically open areas on the Sun from which solar wind rushes out into space).

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Though extreme ultraviolet light shows the Sun's true colors, specialized instruments let us see some of the Sun's most significant activity in visible light.

A coronagraph is a camera that uses a solid disk to block out the Sun’s bright face, revealing the much fainter corona, a dynamic part of the Sun’s atmosphere. Coronagraphs also reveal coronal mass ejections, or CMEs, which are explosions of billions of tons of solar material into space. Because this material is magnetized, it can interact with Earth’s magnetic field and trigger space weather effects like the aurora, satellite problems, and even – in extreme cases – power outages.

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The Sun is also prone to bursts of energetic particles. These particles are blocked by Earth’s magnetic field and atmosphere, but they could pose a threat to astronauts traveling in deep space, and they can interfere with our satellites. This clip shows an eruption of energetic particles impacting a Sun-observing satellite, creating the 'snow' in the image.

Our Sun Is More Than Meets The Eye

We keep watch on the Sun 24/7 with a fleet of satellites to monitor and better understand this activity. And this summer, we’re going one step closer with the launch of Parker Solar Probe, a mission to touch the Sun. Parker Solar Probe will get far closer to the Sun than any other spacecraft has ever gone – into the corona, within 4 million miles of the surface – and will send back unprecedented direct measurements from the regions thought to drive much of the Sun’s activity. More information about the fundamental processes there can help round out and improve models to predict the space weather that the Sun sends our way.

Keep up with the latest on the Sun at @NASASun on Twitter, and follow along with Parker Solar Probe’s last steps to launch at nasa.gov/solarprobe.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com. 


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8 years ago

Juno Spacecraft: What Do We Hope to Learn?

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The Juno spacecraft has been traveling toward its destination since its launch in 2011, and is set to insert Jupiter’s orbit on July 4. Jupiter is by far the largest planet in the solar system. Humans have been studying it for hundreds of years, yet still many basic questions about the gas world remain.

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The primary goal of the Juno spacecraft is to reveal the story of the formation and evolution of the planet Jupiter. Understanding the origin and evolution of Jupiter can provide the knowledge needed to help us understand the origin of our solar system and planetary systems around other stars.

Juno Spacecraft: What Do We Hope To Learn?

Have We Visited Jupiter Before? Yes! In 1995, our Galileo mission (artist illustration above) made the voyage to Jupiter. One of its jobs was to drop a probe into Jupiter’s atmosphere. The data showed us that the composition was different than scientists thought, indicating that our theories of planetary formation were wrong.

What’s Different About This Visit? The Juno spacecraft will, for the first time, see below Jupiter’s dense clover of clouds. [Bonus Fact: This is why the mission was named after the Roman goddess, who was Jupiter’s wife, and who could also see through the clouds.]

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Unlocking Jupiter’s Secrets

Specifically, Juno will…

Determine how much water is in Jupiter’s atmosphere, which helps determine which planet formation theory is correct (or if new theories are needed)

Look deep into Jupiter’s atmosphere to measure composition, temperature, cloud motions and other properties

Map Jupiter’s magnetic and gravity fields, revealing the planet’s deep structure

Explore and study Jupiter’s magnetosphere near the planet’s poles, especially the auroras – Jupiter’s northern and southern lights – providing new insights about how the planet’s enormous

Juno will let us take a giant step forward in our understanding of how giant planets form and the role these titans played in putting together the rest of the solar system.

For updates on the Juno mission, follow the spacecraft on Facebook, Twitter, YouTube and Tumblr.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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5 years ago

uhmm, can you tell me what exactly a black hole is? or what iy does? thanks, just really confused and curious on how it actually works.


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2 months ago

Moon Mascot Needed!

Have you ever wanted to design something that could fly around the Moon? This is your opportunity. The Artemis II astronauts will use a zero gravity indicator during their mission to demonstrate when the Orion spacecraft has reached microgravity. This plushie needs to be soft, small, and importantly, remind us of home. The Moon Mascot contest challenges people of all ages from all over the world to submit a design to be made by NASA’s Thermal Blanket Lab and flown aboard Artemis II. To submit a design for the contest, visit: freelancer.com/moon-mascot


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5 years ago

You Don’t Have to be a Rocket Scientist to Conduct Research in Microgravity

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Putting your life’s work on top of a rocket may seem like a daunting task, but that’s exactly what scientists have been doing for decades as they launch their research to the International Space Station.

This season on #NASAExplorers, we’re exploring why we send science to space, and what it takes to get it there! 

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Watch this week’s episode to meet a team of researchers who are launching an experiment to space for the first time.

Follow NASA Explorers on Facebook to catch new episodes of season 4 every Wednesday!

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com


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