Two Are Better Than One: The NASA Twins Study

Two are Better Than One: The NASA Twins Study

What exactly happens to the human body during spaceflight? The Twins Study, a 340-day investigation conducted by NASA’s Human Research Program , sought to find answers. Scientists had an opportunity to see how conditions on the International Space Station translated to changes in gene expression by comparing identical twin astronauts: Scott Kelly who spent close to a year in space and Mark Kelly who remained on Earth.

The Process

From high above the skies, for almost a year, astronaut Scott Kelly periodically collected his own blood specimens for researchers on the ground during his One-Year Mission aboard the Space Station. These biological specimens made their way down to Earth onboard two separate SpaceX Dragon vehicles. A little bit of Scott returned to Earth each time and was studied by scientists across the United States.

Totaling 183 samples from Scott and his brother, Mark, these vials helped scientists understand the changes Scott’s body underwent while spending a prolonged stay in low Earth orbit.

The Twins

Because identical twins share the same genetic makeup, they are very similar on a molecular level. Twin studies provide a way for scientists to explore how our health is impacted by the environment around us.

What We Learned: Gene Expression

A significant finding is the variability in gene expression, which reflects how a body reacts to its environment and will help inform how gene expression is related to health risks associated with spaceflight. While in space, researchers observed changes in the expression of Scott’s genes, with the majority returning to normal after six months on Earth. However, a small percentage of genes related to the immune system and DNA repair did not return to baseline after his return to Earth. Further, the results identified key genes to target for use in monitoring the health of future astronauts and potentially developing personalized countermeasures.

What We Learned: Immunome

Another key finding is that Scott’s immune system responded appropriately in space. For example, the flu vaccine administered in space worked exactly as it does on Earth. A fully functioning immune system during long-duration space missions is critical to protecting astronaut health from opportunistic microbes in the spacecraft environment.

What We Learned: Proteomics

Studying protein pathways in Scott enabled researchers to look at fluid regulation and fluid shifts within his body. Shifts in fluid may contribute to vision problems in astronauts. Scientists found a specific protein associated with fluid regulation was elevated in Scott, compared with his brother Mark on Earth.

What We Learned: Telomeres

The telomeres in Scott’s white blood cells, which are biomarkers of aging at the end of chromosomes, were unexpectedly longer in space then shorter after his return to Earth with average telomere length returning to normal six months later. In contrast, his brother’s telomeres remained stable throughout the entire period. Because telomeres are important for cellular genomic stability, additional studies on telomere dynamics are planned for future one-year missions to see whether results are repeatable for long-duration missions.

What We Learned: Cognition

Scott Kelly participated in a series of cognitive performance evaluations (such as mental alertness, spatial orientation, and recognition of emotions) administered through a battery of tests and surveys. Researchers found that during spaceflight, Scott’s cognitive function remained normal for the first half of his stay onboard the space station compared to the second half of his spaceflight and to his brother, Mark, on the ground. However, upon landing, Scott’s speed and accuracy decreased. Re-exposure to Earth’s gravity and the dynamic experience of landing may have affected the results.

What We Learned: Biochemical

In studying various measurements on Scott, researchers found that his body mass decreased during flight, likely due to controlled nutrition and extensive exercise. While on his mission, Scott consumed about 30% less calories than researchers anticipated. An increase in his folate serum (vitamin B-9), likely due to an increase of the vitamin in his pre-packaged meals, was also noted by researchers. This is bolstered by the telomeres study, which suggests that proper nutrition and exercise help astronauts maintain health while in space.

What We Learned: Metabolomics

Within five months of being aboard the space station, researchers found an increase in the thickness of Scott’s arterial wall, which may have been caused by inflammation and oxidative stress during spaceflight. Whether this change is reversible is yet to be determined. They hope these results will help them understand the stresses that the human cardiovascular system undergoes during spaceflight.

In addition, the results from the Microbiome, Epigenomics, and Integrative Omics studies suggest a human body is capable of adapting to and recovering from the spaceflight environment on a molecular level.

Why Does This Matter?

The data from the Twins Study Investigation will be explored for years to come as researchers report some interesting, surprising, and assuring data on how the human body is able to adapt to the extreme environment of spaceflight. This study gave us the first integrated molecular view into genetic changes, and demonstrated the plasticity and robustness of a human body!

We will use the valuable data to ensure the safety and health of the men and women who go on to missions to the Moon and on to Mars.

Learn more with this video about these fascinating discoveries!

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Astronaut Journal Entry - Alarms

Currently, six humans are living and working on the International Space Station, which orbits 250 miles above our planet at 17,500mph. Below you will find a real journal entry, written in space, by NASA astronaut Scott Tingle.

To read more entires from this series, visit our Space Blogs on Tumblr.

The smoke detectors have been setting off alarms. This happens routinely due to dust circulating in the modules, but every alarm is taken seriously. This is the third time that the alarm has sounded while I was using the Waste & Hygiene Compartment (toilet). I am starting to think that my actions are causing the alarms…. maybe I should change my diet?

Find more ‘Captain’s Log’ entries HERE.

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8 years ago

Solar System: 10 Things to Know This Week

State of the Solar System: 10 quick updates from around our galactic neighborhood.

1. Powered by the Sun

Fifty-nine years ago, Vanguard 1 launched to demonstrate a new spacecraft technology – solar power. We’ve been going farther and for longer ever since.

+More on Vanguard 1

2. Mapping Mercury

A big week in history for exploration of the innermost planet. On March 16, 1975, our Mariner 10 made its third and final flyby of Mercury. One day and 36 years later, MESSENGER became the first spacecraft to orbit Mercury. Next up: ESA’s BepiColumbo, undergoing testing now, is set to launch for Mercury in 2018.

+Missions to Mercury

3. Return to Venus

U.S. and Russian scientists are discussing a planned revival of the successful Venera program that revealed much about Venus in the 1960s, 70s and 80s. Meanwhile, Japan’s Akatsuki orbiter continues to study our sister planet.

+More on Venera-D

4. Rocket Power

Back on Earth 91 years ago (March 16, 1926), inventor and dreamer Robet Goddard changed the world forever with the first test of a liquid-fueled rocket. We’ve been going farther and faster ever since.

+More on Goddard

5. Moon Watch

Our Lunar Reconnaissance Orbiter (LRO) has been sending a steady stream of high-resolution images back to Earth for more than seven years.

+More on LRO

6. Busy Mars

There are currently five orbiters (Mars Reconnaissance Orbiter, Mars Odyssey, MAVEN, ESA’s Mars Express and India’s Mars Orbiter Mission) and two rovers (Curiosity and Opportunity) exploring Mars, making it second only to Earth in the number of robotic spacecraft studying its secrets.

+Meet the Mars Fleet

7. Vote for Jupiter

Polls close today (March 20) so vote not to point a real spacecraft camera at Jupiter during the mission’s 5th perijove pass.

+Vote now

8. Science to the Last Second

In a little less than six months, our Cassini orbiter will plunge into Saturn as a spectacular finale to its 19-year mission – but not before it embarks on a completely new mission into unexplored space between Saturn and its mighty rings.

+More on Cassini’s Grand Finale

9. By George?

Happy belated birthday to Uranus, discovered on March 13, 1781 by William Herschel. The English astronomer wanted to name his discovery – the first planet discovered in recorded history – “Georgium Sidus” after England’s King George III. But he was overruled, and astronomer stuck with traditional mythological names – creating an opportunity for 263 years of student jokes at the expense of the ice giant planet’s name.

+More on Uranus

10. Go Farther

The round trip light time from Voyager 1 to Earth is more than 38 hours. Voyager 1 is almost 13 billion miles from our home planet.

+More on Voyager

Discover more lists of 10 things to know about our solar system HERE.

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5 years ago

How We’re Accelerating Our Missions to the Moon

Our Space Launch System isn’t your average rocket. It is the only rocket that can send our Orion spacecraft, astronauts and supplies to the Moon. To accomplish this mega-feat, it has to be the most powerful rocket ever built. SLS has already marked a series of milestones moving it closer to its first launch, Artemis.

Here are four highlights you need to know about — plus one more just on the horizon.

Counting Down

Earlier this month, Boeing technicians at our Michoud Assembly Facility in New Orleans successfully joined the top part to the core stage with the liquid hydrogen tank. The core stage will provide the most of the power to launch Artemis 1. Our 212-foot-tall core stage, the largest the we have ever built, has five major structural parts. With the addition of the liquid hydrogen tank to the forward join, four of the five parts have been bolted together. Technicians are finishing up the final part — the complex engine section — and plan to bolt it in place later this summer.

Ready to Rumble

This August, to be exact. That’s when the engines for Artemis 1 will be added to the core stage. Earlier this year, all the engines for the first four SLS flights were updated with controllers, tested and officially cleared “go” for launch. We’ve saved time and money by modifying 16 RS-25 engines from the space shuttle and creating a more powerful version of the solid rocket boosters that launched the shuttle. In April, the last engine from the shuttle program finished up a four-year test series that included 32 tests at our Stennis Space Center near Bay St. Louis, Mississippi. These acceptance tests proved the engines could operate at a higher thrust level necessary for deep space travel and that new, modernized flight controllers —the “brains” of the engine — are ready to send astronauts to the Moon in 2024.

Getting a Boost

Our industry partners have completed the manufacture and checkout of 10 motor segments that will power two of the largest propellant boosters ever built. Just like the engines, these boosters are designed to be fast and powerful. Each booster burns six tons of propellant every second, generating a max thrust of 3.6 million pounds for two minutes of pure awesome. The boosters will finish assembly at our Kennedy Space Center in Florida and readied for the rocket’s first launch in 2020. In the meantime, we are well underway in completing the boosters for SLS and Orion’s second flight in 2022.

Come Together

Meanwhile, other parts of the rocket are finished and ready for the ride to the Moon. The final piece of the upper part of the rocket, the launch vehicle stage adapter, will soon head toward Kennedy Space Center in Florida. Two other pieces, including the interim cryogenic propulsion stage that will provide the power in space to send Orion on to the Moon, have already been delivered to Kennedy.

Looking to the Future

Our engineers evaluated thousands of designs before selecting the current SLS rocket design. Now, they are performing critical testing and using lessons learned from current assembly to ensure the initial and future designs are up to the tasks of launching exploration missions for years to come. This real-time evaluation means engineers and technicians are already cutting down on assembly time for future mission hardware, so that we and our partners can stay on target to return humans to the Moon by 2024 — to stay so we can travel on to Mars.

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5 years ago

Reviving the Shriveled Lake Urmia

Once the second-largest saltwater lake in the Middle East, Lake Urmia attracted birds and bathers to bask in its turquoise waters in northwest Iran. Then beginning in the 1970s, nearly three decades of drought and high water demands on the lake shriveled the basin, shrinking it by 80 percent. Recent torrential rains have replenished the water levels of this aquatic gem once known as “the turquoise solitaire of Azerbaijan.”

The animation above shows Lake Urmia on April 9, 2018, and April 12, 2019. The images were acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) on our Terra satellite. Officials report that the lake’s surface area reached roughly 3,000 square kilometers (1,200 square miles) in April 2019—expanding its volume nearly two-fold from a year ago.

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5 years ago

NASA Spotlight: Brandon Rodriguez, Jet Propulsion Laboratory Education Specialist

Brandon Rodriguez is an education specialist at our Jet Propulsion Laboratory (JPL) in Pasadena, California where he provides resources and training to K-12 schools across the Southwest. Working with a team at JPL, he develops content for classroom teachers, visits schools and speaks with students and trains future teachers to bring NASA into their classroom. When he’s not in the classroom, Brandon’s job takes him on research expeditions all around the world, studying our planet’s extreme environments.

Fun fact: Brandon wakes up every morning to teach an 8 a.m. physics class at a charter school before heading to JPL and clocking in at his full time job. When asked why? He shared, “The truth is that I really feel so much better about my role knowing that we’re not ‘telling’ teachers what to do from our ivory tower. Instead, I can “share” with teachers what I know works not just in theory, but because I’m still there in the classroom doing it myself.” - Brandon Rodriguez

Brandon took time from exciting the next generation of explorers to answer some questions about his life and his career:

What inspired you to work in the educational department at NASA?

I was over the moon when I got a call from NASA Education. I began my career as a research scientist, doing alternative energy work as a chemist. After seven years in the field, I began to feel as if I had a moral responsibility to bring access to science to a the next generation. To do so, I quit my job in science and became a high school science teacher. When NASA called, they asked me if I wanted a way to be both a scientist and an educator- how could I resist?

You were born in Venezuela and came to the U.S. when you were 12 years old. Can you tell us the story of why and how you came to America?

I haven't been back to Venezuela since I was very young, which has been very difficult for me. Being an immigrant in the USA sometimes feels like you're an outsider of both sides: I'm not truly Latin, nor am I an American. When I was young, I struggled with this in ways I couldn't articulate, which manifested in a lot of anger and got me in quite a bit of trouble. Coming to California and working in schools that are not only primarily Latinx students, but also first generation Latinx has really helped me process that feeling, because it's something I can share with those kids. What was once an alienating force has become a very effective tool for my teaching practice.

Does your job take you on any adventures outside of the classroom and if so, what have been your favorite endeavors?

I'm so fortunate that my role takes me all over the world and into environments that allow to me to continue to develop while still sharing my strengths with the education community. I visit schools all over California and the Southwest of the USA to bring professional development to teachers passionate about science. But this year, I was also able to join the Ocean Exploration Trust aboard the EV Nautilus as we explored the Pacific Remote Island National Marine Monument. We were at sea for 23 days, sailing from American Samoa to Hawaii, using submersible remotely operated vehicles to explore the ocean floor.

Image Credit: Nautilus Live

We collected coral and rock samples from places no one has ever explored before, and observed some amazing species of marine creatures along the way.

Image Credit: Nautilus Live

What keeps you motivated to go to work every day?

There's no greater motivation than seeing the product of your hard work, and I get that everyday through students. I get to bring them NASA research that is "hot off the press" in ways that their textbooks never can. They see pictures not online or on worksheets, but from earlier that day as I walked through JPL. It is clearly that much more real and tangible to them when they can access it through their teacher and their community.

Do you have any tips for people struggling with their science and math classes?

As someone who struggled- especially in college- I want people to know that what they struggle with isn't science, it's science classes. The world of research doesn't have exams; it doesn't have blanks to be filled in or facts to be memorized. Science is exploring the unknown. Yes, of course we need the tools to properly explore, and that usually means building a strong academic foundation. But it helped me to differentiate the end goal from the process: I was bad at science tests, but I wanted to someday be very good at science. I could persevere through the former if it got me to the latter.

If you could safely visit any planet, star, or solar system, where would you visit and what would you want to learn?

Europa, without a doubt. Imagine if we found even simple life once more in our solar system- and outside of the habitable zone, no less. What would this mean for finding life outside of our solar system as a result? We would surely need to conclude that our sky is filled with alien worlds looking back at us.

Is there a moment or project that you feel defined (or significantly impacted) your career up to today?

While I never worked closely with the mission, Insight was a really important project for me. It's the first time while at JPL I was able to see the construction, launch and landing of a mission.

If you could name a spaceship, what would you name it?

For as long as I can remember, I've been watching and reading science fiction, and I continue to be amazed at how fiction informs reality. How long ago was it that in Star Trek, the crew would be handing around these futuristic computer tablets that decades later would become common iPads? In their honor, I would be delighted if we named a ship Enterprise.

Thanks so much Brandon!

Additional Image Credit: MLParker Media

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7 years ago

Meet America’s new astronauts! These 12 humans have been selected as part of our 2017 astronaut class and will report for duty at our Johnson Space Center in August.

Get to know each of them here: https://nasa.tumblr.com/post/161552645129/meet-americas-newastronauts

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4 years ago

What’s Up in December 2020 – Skywatching Tips from NASA!

Catch the Geminids meteor shower as the peak coincides with darker skies during a new Moon. Plus, Jupiter and Saturn appear closer than in decades, and the winter solstice arrives. Check this out for when and where to observe! Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

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9 years ago

The NASA “Worm” Logo

Just like many organizations, the style and logos can change over time. You are probably most familiar with our “meatball” logo. No, unfortunately this does not refer to the delicious food. This logo (below) is our most popular symbol, and dates back to 1959.

But, we’ve also had other insignia that represented our organization throughout the years.

The “worm” logo (below) was used by the agency from 1975 until 1992. The organization wanted to create a more “modern” logo, which resulted in the unique type style of the “worm” logo.

Even though this logo was retired in 1992, the Graphics Standards Manual is still available online HERE.

You can also read up about the emblems, logos and insignia used by NASA throughout the years in a new e-Book available for free HERE.

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7 years ago

The 2017 Atlantic Hurricane Season: What We Learned

The 2017 Atlantic hurricane season was among the top ten most active seasons in recorded history. Our experts are exploring what made this year particularly active and the science behind some of the biggest storms to date.

After a period of 12 years without a Category 3 or higher hurricane making landfall in the U.S., Hurricane Harvey made landfall over Texas as a Category 4 hurricane this August.

Harvey was also the biggest rainfall event ever to hit the continental U.S. with estimates more than 49 inches of rain.

Data like this from our Global Precipitation Measurement Mission, which shows the amount of rainfall from the storm and temperatures within the story, are helping scientists better understand how storms develop.

The unique vantage point of satellites can also help first responders, and this year satellite data helped organizations map out response strategies during hurricanes Harvey, Irma and Maria.  

In addition to satellites, we use ground stations and aircraft to track hurricanes.

We also use the capabilities of satellites like Suomi NPP and others that are able to take nighttime views. In this instance, we were able to view the power outages in Puerto Rico. This allowed first responders to see where the location of impacted urban areas.

The combined effort between us, NOAA, FEMA and other federal agencies helps us understand more about how major storms develop, how they gain strength and how they affect us.